Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits
Acta cir. bras
; Acta cir. bras;33(11): 954-963, Nov. 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-973477
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.Methods:
14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study.Results:
There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p> 0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482).Conclusions:
Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Neuromuscular Nondepolarizing Agents
/
Iridoids
/
Rocuronium
/
Anesthesia, General
/
Mast Cells
/
Anti-Inflammatory Agents
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Document type:
Article
Affiliation country:
Turquía
Country of publication:
Brasil