Lymphocytes and B-cell abnormalities in patients with common variable immunodeficiency (CVID)
Allergol. immunopatol
; 42(1): 35-43, ene.-feb. 2014. tab, graf, ilus
Article
in En
| IBECS
| ID: ibc-119051
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND AND AIMS:
Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised by decreased antibody production and low or normal B-cell numbers. To elucidate the clinical and immunological heterogeneity of CVID, we studied 16 patients diagnosed with CVID.Methods:
We analysed B, T and NK cell populations. We also assessed CD27 expression to define B-cell subsets and examined the expression of molecules important in B-cell proliferation and differentiation, such as the transmembrane activator and CALM interactor (TACI), inducible costimulator (ICOS), CD154 and CD40.Results:
We observed reduced B and T-cell numbers in CVID patients; this reduction was more pronounced in adults. While one group of patients (group I) showed a significant reduction in CD27+ memory B-cells, another group (group II) of patients exhibited numbers of CD27+ memory B-cells similar to the healthy donor. The frequency of B-cells and T-cells expressing CD40 and ICOS, respectively, was significantly lower in all CVID patients compared with healthy donors. Finally, a correlation between the frequency of CD27+ memory B-cells and clinical features was observed in CVID patients.Conclusion:
These results suggest that in some patients, the combined defects in both T and B-cells may account for CVID. Additionally, patients in group I exhibited an increased frequency of pneumonia and chronic diarrhoeaRESUMEN
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
B-Lymphocytes
/
Common Variable Immunodeficiency
/
Hypersensitivity
Limits:
Humans
Language:
En
Journal:
Allergol. immunopatol
Year:
2014
Document type:
Article