Characterization of NDM-1- and CMH-3-producing Enterobacter cloacae complex ST932 in a patient transferred from Ukraine to Spain / Caracterización de Enterobacter cloacae complex ST932 productor de NDM-1 y CMH-3 en un paciente trasladado desde Ucrania a España
Enferm. infecc. microbiol. clín. (Ed. impr.)
; 38(7): 327-330, ago.-sept. 2020. tab, graf
Article
in En
| IBECS
| ID: ibc-201302
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION: To characterize a carbapenem-resistant Enterobacter cloacae complex isolate recovered from a patient from Ukraine. METHODS: The isolate was sent to a regional reference laboratory for molecular characterization by whole genome sequencing. Susceptibility assays, carbapenemase identification, imipenem hydrolysis and clonality were performed. RESULTS: The isolate showed resistance or reduced susceptibility to all β-lactam agents tested. Genome analysis led to the identification of an NDM-1-producing E. cloacae complex strain that was assigned to a new multilocus sequence type, ST932. The blaNDM-1 enzyme was located in a conjugative IncX3 plasmid of ca. 50kb. In addition, blaCMH-3, a recently described AmpC β-lactamase sequence, which has not previously been reported in Europe, was also detected and its genetic environment was studied. CONCLUSION: To our knowledge, this is the first reported case in Europe of an E. cloacae complex strain that produces both blaNDM-1 and blaCMH-3
Search on Google
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Enterobacter cloacae
/
Enterobacteriaceae Infections
/
Carbapenem-Resistant Enterobacteriaceae
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Enferm. infecc. microbiol. clín. (Ed. impr.)
Year:
2020
Document type:
Article