The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia / Los genotipos y atributos de virulencia de aislamientos de C. albicans de leucoplasia oral
Med. oral patol. oral cir. bucal (Internet)
; 26(6): e786-e794, Nov. 2021. tab
Article
in En
| IBECS
| ID: ibc-224683
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background: There is a debate as to whether some types of oral leucoplakias (OL) are caused by Candida species,and whether they contribute to the malignant transformation, associated with a minority of such lesions. As nodetailed population analysis of yeast isolates from OL is available, we evaluated the virulence attributes, and geno-types of 35 C. albicans from OL, and compared their genotypes with 18 oral isolates from healthy individuals.Material and Methods: The virulence traits evaluated were esterase, phospholipase, proteinase, haemolysin andcoagulase production, and phenotypic switching activity, and yeast adherence and biofilm formation. DNA fromOL and control yeasts were evaluated for A, B or C genotype status.Results: Phospholipase, proteinase, and coagulase activity and biofilm formation was observed in 80%, 66%, 97% and 77 % of the isolates, respectively. Phenotypic switching was detected in 8.6%, while heamolytic, and ester-ase activity and adherence were noted in all isolates.Conclusions: The genotype A was predominant amongst both the OL and control groups. Due to the small samplesize of our study a larger investigation to define the role of candidal virulent attributes in the pathogenicity of OLis warranted, and the current data should serve as a basis until then.(AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Candida albicans
/
Leukoplakia, Oral
/
Virulence Factors
/
Mouth
Limits:
Humans
Language:
En
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2021
Document type:
Article