BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis - review
Mem. Inst. Oswaldo Cruz
; 100(5): 459-465, Aug. 2005. ilus
Article
in En
| LILACS
| ID: lil-409960
Responsible library:
BR1.1
RESUMO
The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seventies when it was replaced by the intradermal route. This change in route of delivery was mainly secondary to pressure by medical practitioners based on the poor responses of oral immunized subjects to purified protein derivative (PPD) skin tests. Even after the change of route of delivery, Ataulpho de Paiva Foundation continued making the oral vaccine. Currently, BCG Moreau has been described as one of the most immunogenic and with fewer side effects than other BCGs. The genomics, proteomics and vaccine trials for oral BCG Moreau Rio de Janeiro are currently under investigation. In this review, we intend to describe the history of BCG Moreau Rio de Janeiro in Brazil.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Tuberculosis, Pulmonary
/
BCG Vaccine
/
Vaccination
Limits:
Humans
/
Infant
/
Newborn
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2005
Document type:
Article
Affiliation country:
Brasil
/
Reino Unido
Publication country:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL