Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Acta cir. bras
; Acta cir. bras;29(10): 667-674, 10/2014. tab, graf
Article
in En
| LILACS
| ID: lil-725291
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To investigate E-cadherin immunoexpression during cervical carcinogenesis.METHODS:
We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis.RESULTS:
The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis.CONCLUSIONS:
E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Carcinoma, Squamous Cell
/
Cadherins
/
Uterine Cervicitis
/
Uterine Cervical Neoplasms
/
Squamous Intraepithelial Lesions of the Cervix
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Document type:
Article
Affiliation country:
Brasil
Country of publication:
Brasil