Massive splenomegaly and Epstein-Barr virus-associated infectious mononucleosis in a patient with Gaucher disease.
J Pediatr Hematol Oncol
; 21(1): 47-9, 1999.
Article
in En
| MEDLINE
| ID: mdl-10029812
ABSTRACT
PURPOSE:
Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly. PATIENTS ANDMETHODS:
A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of beta-glucosidase enzyme activity.RESULTS:
Regression of splenomegaly and improving hematologic indices.CONCLUSION:
Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Splenomegaly
/
Herpesvirus 4, Human
/
Gaucher Disease
/
Infectious Mononucleosis
Type of study:
Risk_factors_studies
Limits:
Adolescent
/
Humans
/
Male
Language:
En
Journal:
J Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos