N,N-disubstituted aminomethyl benzofuran derivatives: synthesis and preliminary binding evaluation.
Bioorg Med Chem
; 7(2): 335-41, 1999 Feb.
Article
in En
| MEDLINE
| ID: mdl-10218826
ABSTRACT
A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3, D2, and D3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro -2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9 -dione, bound at 5-HT1A sites with nanomolar affinity (IC50= 1.5 nM) and high selectivity over 5-HT2A, 5-HT2C, 5-HT3, D2, and D3 receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzofurans
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
1999
Document type:
Article
Affiliation country:
Francia