Voluntary consumption of amphetamine, cocaine, ethanol and morphine by rats as influenced by a preceding period of forced drug intake and clozapine.
Pharmacology
; 58(6): 285-91, 1999 Jun.
Article
in En
| MEDLINE
| ID: mdl-10325573
ABSTRACT
Forced nicotine intake was previously found to decrease a subsequent free choice selection, whereas clozapine (CL) caused a marked increase in its consumption. Here these findings are extended to ethanol, cocaine, morphine and amphetamine. Forced intake of ethanol, cocaine, morphine and amphetamine had no major effect on a subsequent voluntary intake. CL, a dopamine D4 antagonist, increased the voluntary consumption of amphetamine and morphine with no effects on ethanol or cocaine intake. Only for cocaine was it found that low-consuming rats increased but high-consuming rats decreased their voluntary cocaine intake by CL. Thus, forced drug exposure per se does not lead to subsequent enhancement of voluntary intake; CL exerts differential effects on intake of these drugs, and a specific dopaminergic set point may govern the voluntary intake of cocaine by individual rats.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Self Administration
/
Dopamine Agents
/
Central Nervous System Depressants
/
Clozapine
/
Cocaine
/
Ethanol
/
Amphetamine
/
Morphine
/
Narcotics
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Pharmacology
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos