Immune response to a recombinant fragment of the CagA protein of Helicobacter pylori in blood donors and patients with gastric cancer: relation to ABO(H) blood group phenotype, stage of the disease and tumor morphology.
Med Microbiol Immunol
; 187(4): 227-32, 1999 May.
Article
in En
| MEDLINE
| ID: mdl-10363680
ABSTRACT
IgG immune response to CagA was evaluated by enzyme-linked imunosorbent assay (ELISA) using a recombinant fragment of CagA as antigen in 171 patients with gastric cancer and 298 blood donors to determine whether it could be related to the ABO(H) blood group phenotype, stage of cancer or tumor morphology. The CagA-ELISA showed a good specificity (93.5%) and sensitivity (88.5%) as compared with immunoblotting for blot CagA-negative and -positive donors. The Helicobacter pylori seropositive blood group A donors revealed the lowest proportion (37.6%) of strong responders to CagA A
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Bacterial Proteins
/
ABO Blood-Group System
/
Helicobacter pylori
/
Helicobacter Infections
/
Antibodies, Bacterial
/
Antigens, Bacterial
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Med Microbiol Immunol
Year:
1999
Document type:
Article