Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport.
Hum Mol Genet
; 8(7): 1263-9, 1999 Jul.
Article
in En
| MEDLINE
| ID: mdl-10369872
ABSTRACT
Presenilin 1 (PS1) mutations account for the majority of early-onset dominant cases of familial Alzheimer's disease. Presenilins (PSs) are located in many intra-cellular compartments such as the endoplasmic reticulum, Golgi apparatus, nuclear region and vesicular structures. These proteins include from seven to nine putative transmembrane domains, with the N- and C-terminal ends and a large hydrophilic loop orientated towards the cytoplasm. We report an interaction between the human PS1 or PS2 hydrophilic loop and Rab11, a small GTPase belonging to the Ras-related superfamily. Interaction domains were mapped to codons 374-400 for PS1 and to codons 106-179 for Rab11, a region including the fourth GTP-binding domain. Considering the implication of Rab proteins in vesicular transport pathways, the PS-Rab11 inter-action suggests that PSs might be involved in amyloid precursor protein vesicular routing.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
GTP-Binding Proteins
/
Rab GTP-Binding Proteins
/
GTP Phosphohydrolases
/
Membrane Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Hum Mol Genet
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Year:
1999
Document type:
Article
Affiliation country:
Francia