[Chronic HCV hepatopathy and cryoglobulinemia. The associated clinical spectrum]. / Epatopatia cronica da HCV e crioglobulinemia. Lo spettro clinico associato.
Minerva Med
; 90(1-2): 1-5, 1999.
Article
in It
| MEDLINE
| ID: mdl-10388457
ABSTRACT
BACKGROUND AND AIM:
The hepatitis C infection (HCV) has numerous extrahepatic manifestations owing to the systemic nature of the infection itself. HCV infects the cells that carry a CD 81 receptor and show a marked tropism for hepatocytes, bone marrow staminal cells and circulating lymphomonocytes. One consequence of this tropism is the activation of B lymphocyte clones with the consequent production of autoantibodies and cryoglobulins. The secondary event is the formation of circulating immune complexes which, having precipitated at an intravascular level, may cause part of the extrahepatic manifestations associated with these infections.METHODS:
This retrospective study evaluated the manifestations correlated and/or associated with HCV hepatitis and mixed cryoglobulinaemia.RESULTS:
This analysis showed that 75% of consecutively studied patients reveal clinically important extrahepatic manifestations.CONCLUSIONS:
This underlines the "broad spectrum" action played by the hepatitis C virus in the host organism.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis C, Chronic
/
Cryoglobulinemia
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Minerva Med
Year:
1999
Document type:
Article