Identification of a new, unorthodox member of the MAGE gene family.
Genomics
; 59(2): 161-7, 1999 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-10409427
ABSTRACT
Several tumor-associated antigen families, such as MAGE, GAGE/PAGE, PRAME, BAGE, and LAGE/NY-ESO-1, exist. These antigens are of particular interest in tumor immunology, because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells only. We have identified a novel member of the MAGE gene family, MAGED1. Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult tissues is comparable to that in testis and fetal liver. Thus, MAGED1 does not possess an expression pattern characteristic of previously identified MAGE family genes, suggesting that the biology of the MAGE-family genes is more complex than previously thought. Chromosome mapping linked MAGED1 to marker AFM119xd6 (DXS1039) on chromosome Xp11.23.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplasm Proteins
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Genomics
Journal subject:
GENETICA
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos