Migration of mesonephric cells into the mammalian gonad depends on Sry.
Mech Dev
; 84(1-2): 127-31, 1999 Jun.
Article
in En
| MEDLINE
| ID: mdl-10473126
ABSTRACT
In mammals, the primary step in male sex determination is the initiation of testis development which depends on the expression of the Y-linked testis determining gene, Sry. The mechanisms by which Sry controls this process are unknown. Studies showed that cell migration from the adjacent mesonephros only occurs into XY gonads; however, it was not known whether this effect depended on Sry, another Y-linked gene, or the presence of one versus two X chromosomes. Here we provide genetic proof that Sry is the only Y-linked gene necessary for cell migration into the gonad. Cell migration from the mesonephros into the differentiating gonad is consistently associated with Sty's presence and with testis cord formation, suggesting that cell migration plays a critical role in the initiation of testis cord development. The induction of cell migration represents the earliest signaling pathway yet assigned to Sry.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Nuclear Proteins
/
Gene Expression Regulation, Developmental
/
DNA-Binding Proteins
/
Gonads
/
Mesonephros
Limits:
Animals
Language:
En
Journal:
Mech Dev
Journal subject:
EMBRIOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos