ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Diabetes Metab Res Rev
; 15(4): 247-53, 1999.
Article
in En
| MEDLINE
| ID: mdl-10495473
ABSTRACT
BACKGROUND:
Genetic factors are involved in the development of diabetic nephropathy in Type 1 diabetes. We have examined the association of four candidate genes, angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, decorin 179/183/185 polymorphism and Werner syndrome helicase C/R polymorphism, with the presence of diabetic nephropathy in Type 1 diabetic patients.METHODS:
175 Type 1 diabetic patients with albuminuria (59 with microalbuminuria and 116 with macroalbuminuria) were compared with 136 Type 1 diabetic patients with normoalbuminuria and duration of disease longer than 15 years (mean+/-SD 25+/-8 years). 200 non-diabetic subjects were also studied as background population.RESULTS:
We found no association in the polymorphism of the four genes examined between patients with and without diabetic nephropathy and the control subjects.CONCLUSIONS:
The genes studied are unlikely to be involved in the susceptibility to nephropathy in Type 1 diabetic patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteoglycans
/
Plasminogen Activator Inhibitor 1
/
DNA Helicases
/
Peptidyl-Dipeptidase A
/
Diabetes Mellitus, Type 1
/
Diabetic Nephropathies
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Diabetes Metab Res Rev
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
1999
Document type:
Article
Affiliation country:
Italia