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An Ava I polymorphism in the TP53 gene.
Graziani, D; Romagnoli, S; Cassani, B; Alfano, R M; Roncalli, M; Coggi, G.
Affiliation
  • Graziani D; Il Department of Pathology, University of Milan School of Medicine, Via A di Rudinì 8, Milano, 20142, Italy.
Mol Cell Probes ; 13(5): 393-5, 1999 Oct.
Article in En | MEDLINE | ID: mdl-10508562
TP53 gene plays a major role in the process of malignant transformation and tumour progression so that abnormalities such as point mutation or allelic loss of this gene are a common finding in different tumour types. Most of the mutations identified cover a conserved region of the gene, spanning from exon 4 to exon 9. The present report describes a novel polymorphism, 12 nucleotides downstream the splicing junction of exon/intron 9 identified in a cohort of 103 Italian healthy blood donors. The polymorphism results in the creation of a new restriction site for Ava I.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Genes, p53 Type of study: Prognostic_studies Limits: Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Mol Cell Probes Journal subject: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Year: 1999 Document type: Article Affiliation country: Italia Country of publication: Reino Unido
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Collection: 01-internacional Database: MEDLINE Main subject: Genes, p53 Type of study: Prognostic_studies Limits: Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Mol Cell Probes Journal subject: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Year: 1999 Document type: Article Affiliation country: Italia Country of publication: Reino Unido