Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.
J Exp Med
; 190(9): 1319-28, 1999 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-10544203
ABSTRACT
The role of memory T cells during the immune response against random antigenic variants has not been resolved. Here, we show by simultaneous staining with two tetrameric major histocompatibility complex (MHC)-peptide molecules, that the polyclonal CD8(+) T cell response against a series of natural variants of the influenza A nucleoprotein epitope is completely dominated by infrequent cross-reactive T cells that expand from an original memory population. Based on both biochemical and functional criteria, these cross-reactive cytotoxic T cells productively recognize both the parental and the mutant epitope in vitro and in vivo. These results provide direct evidence that the repertoire of antigen-specific T cells used during an infection critically depends on prior antigen encounters, and indicate that polyclonal memory T cell populations can provide protection against a range of antigenic variants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Core Proteins
/
RNA-Binding Proteins
/
CD8-Positive T-Lymphocytes
/
Major Histocompatibility Complex
/
Nucleoproteins
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1999
Document type:
Article
Affiliation country:
Países Bajos