A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
Cancer Res
; 59(22): 5671-3, 1999 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-10582681
ABSTRACT
We have tested a new ligand for peroxisome proliferator-activated receptor-gamma, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the classic rat model with nitrosomethylurea as carcinogen. Rats were first treated with a single dose of nitrosomethylurea (50 mg/kg body weight, i.p.). Starting 1 week later, they were fed GW7845, at either 60 or 30 mg/kg of diet, for 2 months. This agent significantly reduced tumor incidence, tumor number, and tumor weight at both doses. This is the first report of the use of a ligand for peroxisome proliferator-activated receptor-gamma to prevent experimental breast cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxazoles
/
Tyrosine
/
Transcription Factors
/
Anticarcinogenic Agents
/
Receptors, Cytoplasmic and Nuclear
/
Mammary Neoplasms, Experimental
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cancer Res
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos