The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid.
Neurosci Lett
; 276(1): 25-8, 1999 Nov 26.
Article
in En
| MEDLINE
| ID: mdl-10586966
ABSTRACT
In order to examine concentrations of cerebrospinal fluid (CSF) neurochemicals, the technique of lumbar puncture is typically used. However, the effect of the intrinsic stress of undergoing a lumbar puncture on CSF monoamine concentrations in humans has not yet been established. We used lumbar puncture followed 3 h later by continuous CSF sampling to examine the effect of lumbar puncture on levels of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Additionally, we examined the effect of lumbar puncture on the CSF HVA to 5-HIAA ratio. Immediately post lumbar puncture, CSF concentrations of HVA and 5-HIAA were, respectively, only 51 and 54% of the mean levels detected hours later. However, the HVA to 5-HIAA ratio remained stable during lumbar puncture. While HVA and 5-HIAA levels in CSF obtained via lumbar puncture reflect highly variable responses to the stress of the procedure, the ratio of these metabolites is unaffected.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Puncture
/
Stress, Physiological
/
Dopamine
/
Serotonin
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurosci Lett
Year:
1999
Document type:
Article
Affiliation country:
Estados Unidos