n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation.
J Biol Chem
; 275(2): 721-4, 2000 Jan 14.
Article
in En
| MEDLINE
| ID: mdl-10625599
ABSTRACT
This study describes specific molecular mechanisms by which supplementation with n-3 fatty acids (i.e. those present in fish oils) can modulate the expression and activity of degradative and inflammatory factors that cause cartilage destruction during arthritis. Our data show that incorporation of n-3 fatty acids (but not other polyunsaturated or saturated fatty acids) into articular cartilage chondrocyte membranes results in a dose-dependent reduction in (i) the expression and activity of proteoglycan degrading enzymes (aggrecanases) and (ii) the expression of inflammation-inducible cytokines (interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha) and cyclooxygenase (COX-2), but not the constitutively expressed cyclooxygenase COX-1. These findings provide evidence that n-3 fatty acid supplementation can specifically affect regulatory mechanisms involved in chondrocyte gene transcription and thus further advocate a beneficial role for dietary fish oil supplementation in alleviation of several of the physiological parameters that cause and propogate arthritic disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endopeptidases
/
Cartilage, Articular
/
Fatty Acids, Omega-3
/
Gene Expression Regulation
/
Interleukin-1
/
Tumor Necrosis Factor-alpha
/
Prostaglandin-Endoperoxide Synthases
/
Isoenzymes
Limits:
Animals
Language:
En
Journal:
J Biol Chem
Year:
2000
Document type:
Article
Affiliation country:
Reino Unido