Glucose regulates pancreatic preprosomatostatin I expression.
FEBS Lett
; 465(2-3): 115-8, 2000 Jan 14.
Article
in En
| MEDLINE
| ID: mdl-10631316
ABSTRACT
Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreas
/
Protein Precursors
/
Somatostatin
/
Gene Expression Regulation
/
Glucose
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos