Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus.
Gut
; 46(3): 432-4, 2000 Mar.
Article
in En
| MEDLINE
| ID: mdl-10673310
ABSTRACT
Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Neoplasms, Multiple Primary
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Gut
Year:
2000
Document type:
Article
Affiliation country:
Japón