Alterations in the properties and isoforms of sciatic nerve Na(+), K(+)-ATPase in methylcyclopentadienyl manganese tricarbonyl-treated mice.
Environ Res
; 82(3): 239-44, 2000 Mar.
Article
in En
| MEDLINE
| ID: mdl-10702331
ABSTRACT
The in vivo effect of methylcyclopentadienyl manganese tricarbonyl (MMT), an organic manganese-containing compound, on the mouse motor nerve was studied. The motor nerve conduction velocity was markedly decreased in MMT-treated mice. The Na(+),K(+)-ATPase activity of sciatic nerve isolated from MMT-treated mice was decreased; however, the sciatic nerve Na(+),K(+)-ATPase activity was not affected by the in vitro treatment of MMT. Moreover, [(3)H]ouabain binding of sciatic nerve isolated from MMT-treated mice was decreased. Using Western blot analysis, the amount of Na(+),K(+)-ATPase catalytic alpha1 subunit polypeptide in sciatic nerve of MMT-treated mice was also decreased. These results indicate that a causal relationship may exist between reduced nerve Na(+),K(+)-ATPase activity and motor nerve conduction velocity in MMT-treated mice and that a measurable decrease in alpha1 catalytic subunit isoform of Na(+),K(+)-ATPase may be necessary for the development of peripheral neuropathy by MMT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Sciatic Nerve
/
Sodium-Potassium-Exchanging ATPase
/
Neural Conduction
Limits:
Animals
Language:
En
Journal:
Environ Res
Year:
2000
Document type:
Article
Affiliation country:
Taiwán