Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.
Neuron
; 25(1): 29-41, 2000 Jan.
Article
in En
| MEDLINE
| ID: mdl-10707970
ABSTRACT
Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance events throughout neural development. Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axons
/
Glycoproteins
/
Carrier Proteins
/
Nerve Tissue Proteins
Type of study:
Guideline
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos