Polycyclic aromatic hydrocarbon exposure in an artificial shooting target factory: assessment of 1-hydroxypyrene urinary excretion as a biological indicator of exposure.
Ann Occup Hyg
; 44(2): 89-100, 2000 Mar.
Article
in En
| MEDLINE
| ID: mdl-10717260
ABSTRACT
Five representative workers and two external observers were monitored by personal air and urinary 1-hydroxypyrene (PyOH) sampling for a four-shift working week in an artificial shooting target factory. The targets (clay pigeons), are made from petroleum pitch and molded at 190 degrees C. No respiratory protective mask was worn. Atmospheric concentrations of pyrene and benzo (a) pyrene (BaP) ranged from 0.66 to 5.05 microg/m(3) and 0.037 to 0.270 microg/m(3) respectively with a mean pyrene/BaP ratio of about 20 and a correlation r = 0.51. Maximum PyOH urinary excretion ranged from 1.84 to 10.9 micromol/molCreat. This occurred at the postshift for the observers but often appeared later for workers up to 10.75 h for the person with the apparently highest dermal exposure. The apparent PyOH excretion half lives ranged from 1.9 to 12.5 h with an arithmetic mean of 6.1 h. All these data were confirmed by additional measurements taken over a weekend after the postshift. The correlation between atmospheric pyrene and urinary PyOH concentrations (increase over the shift) was poor (r = 0.37). It improve greatly (r = 0.74) if the amount of pyrene inhaled over the shift and the corresponding amount of PyOH excreted were considered. The ratio of urinary excreted PyOH to the pyrene inhaled dose (with assumed retention of 100%), ranged from 0.18 to 0.70 (arithmetic mean = 0.34). This suggests that the respiratory tract is the main entrance route for pyrene (apart from the worker who handled crude targets without gloves).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycyclic Aromatic Hydrocarbons
/
Pyrenes
/
Occupational Exposure
/
Air Pollutants, Occupational
/
Mutagens
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Ann Occup Hyg
Year:
2000
Document type:
Article
Affiliation country:
Francia