Cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat sympatho-adrenal axis.
Neurosci Lett
; 283(2): 97-100, 2000 Apr 07.
Article
in En
| MEDLINE
| ID: mdl-10739884
ABSTRACT
Distribution of cocaine- and amphetamine-regulated transcript-like immunoreactivity (CART-LI) was studied in the rat spinal cord, sympathetic ganglia and adrenal glands by immunohistochemical methods, utilizing a polyclonal antiserum raised against the CART peptide fragment 55-102. CART-LI was detected in nerve fibers and in basket-like terminals surrounding many postganglionic neurons of the superior cervical ganglion (SCG), stellate, paravertebral and prevertebral ganglia. Postganglionic neurons exhibited low or non-detectable levels of CART-LI. Surgical sectioning of the cervical sympathetic trunk for 6-7 days resulted in a nearly complete loss of CART-LI fibers and terminals in the SCG. In the adrenal gland, CART-LI nerve fibers formed a plexus underneath the capsule, some of which bifurcated and made a sharp turn toward the adrenal medulla, where clusters of chromaffin cells were intensely labeled. The detection of CART-LI in sympathetic ganglia and adrenal glands extends the previous observation of the presence of CART-LI in sympathetic preganglionic neurons and further supports the notion that CART peptide(s) may function as a signaling molecule in the sympatho-adrenal axis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription, Genetic
/
Cocaine
/
Ganglia, Sympathetic
/
Amphetamine
/
Nerve Tissue Proteins
/
Neurons
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos