The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases.
Hum Pathol
; 31(3): 380-5, 2000 Mar.
Article
in En
| MEDLINE
| ID: mdl-10746683
ABSTRACT
Rosai-Dorfman disease (RDD), originally described as sinus histiocytosis with massive lymphadenopathy, is a rare histiocytic proliferative disorder with a distinctive microscopic appearance. Formerly thought to be a process limited to lymph nodes, involvement by RDD has now been documented in many organ systems, notably bone, skin and soft tissue, central nervous system, eye and orbit, and upper respiratory tract. The digestive system, however, is affected only exceptionally, as reflected by the existence of only a handful of individual case reports. In this article, we report 11 patients in which the disease involved intestinal tract, liver, or pancreas, and describe the most salient clinicopathologic features. The specific site of involvement within the digestive system was gastrointestinal tract in 5, liver in 5, and pancreas in 1. Most patients also had evidence of disease in other extranodal sites, as well as in 1 or more lymph node groups.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Diseases
/
Histiocytosis, Sinus
/
Intestinal Diseases
/
Liver Diseases
/
Lymph Nodes
/
Lymphatic Diseases
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Language:
En
Journal:
Hum Pathol
Journal subject:
PATOLOGIA
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos