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Diabetic retinopathy is associated with decreased serum levels of free IGF-I and changes of IGF-binding proteins.
Feldmann, B; Jehle, P M; Mohan, S; Lang, G E; Lang, G K; Brueckel, J; Boehm, B O.
Affiliation
  • Feldmann B; Department of Internal Medicine, University of Ulm, Germany.
Growth Horm IGF Res ; 10(1): 53-9, 2000 Feb.
Article in En | MEDLINE | ID: mdl-10753593
ABSTRACT
In patients with diabetic retinopathy, elevated serum levels of total circulating insulin-like growth factor-I (IGF-I) have been implicated as an important mediator of the disease. There is no study, however, measuring free IGF-I levels in patients with diabetic retinopathy which mediate the biological effects of IGF-I and are modulated by a complex system of six specific IGF binding proteins (IGFBPs) and several IGFBP proteases.
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Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Insulin-Like Growth Factor Binding Proteins / Diabetic Retinopathy Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Growth Horm IGF Res Journal subject: ENDOCRINOLOGIA Year: 2000 Document type: Article Affiliation country: Alemania
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Insulin-Like Growth Factor Binding Proteins / Diabetic Retinopathy Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Growth Horm IGF Res Journal subject: ENDOCRINOLOGIA Year: 2000 Document type: Article Affiliation country: Alemania