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Manipulations of the metabolic response for management of patients with severe surgical illness: review.
Connolly, A B; Vernon, D R.
Affiliation
  • Connolly AB; Department of Surgery, University of Auckland, Private Bag, Auckland, New Zealand. andrewc@middlemore.co.nz
World J Surg ; 24(6): 696-704, 2000 Jun.
Article in En | MEDLINE | ID: mdl-10773122
The metabolic response to severe surgical illness is complex and varied. Much recent laboratory and clinical research has focused on increasing our understanding of the metabolic response and the development of new therapies designed to modify this response. Antiinflammatory agents can target harmful aspects of the metabolic response; the immune system can be stimulated; and anabolic factors can be used in an attempt to enhance recovery. The nutritional support of the surgical patient remains crucial, but the effects of new additives are being studied in a variety of surgical conditions. As yet, few of these "novel" agents have found an established role in the management of surgical patients. This review focuses on many "novel" agents or those that do not yet have a clearly defined role in surgical illness. Clinical trials in the areas of severe sepsis, major surgical trauma, and major elective surgery have been emphasized.
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Collection: 01-internacional Database: MEDLINE Main subject: Surgical Procedures, Operative / Sepsis Limits: Animals / Humans Language: En Journal: World J Surg Year: 2000 Document type: Article Affiliation country: Nueva Zelanda Country of publication: Estados Unidos
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Collection: 01-internacional Database: MEDLINE Main subject: Surgical Procedures, Operative / Sepsis Limits: Animals / Humans Language: En Journal: World J Surg Year: 2000 Document type: Article Affiliation country: Nueva Zelanda Country of publication: Estados Unidos