Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population.
Cancer Lett
; 156(2): 159-65, 2000 Aug 11.
Article
in En
| MEDLINE
| ID: mdl-10880765
ABSTRACT
To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype (P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Repressor Proteins
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Oncogene Proteins, Viral
Type of study:
Etiology_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Cancer Lett
Year:
2000
Document type:
Article
Affiliation country:
Japón