In vivo detection of vascular adhesion protein-1 in experimental inflammation.
Am J Pathol
; 157(2): 463-71, 2000 Aug.
Article
in En
| MEDLINE
| ID: mdl-10934150
ABSTRACT
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial glycoprotein which mediates leukocyte-endothelial cell interactions. To study the pathogenetic significance of VAP-1 in inflammatory disorders, an in vivo immunodetection method was used to detect the regulation of luminally expressed VAP-1 in experimental skin and joint inflammation in the pig and dog. Moreover, VAP-1 was studied as a potential target to localize inflammation by radioimmunoscintigraphy. Up-regulation of VAP-1 in experimental dermatitis and arthritis could be visualized by specifically targeted immunoscintigraphy. Moreover, the translocation of VAP-1 to the functional position on the endothelial surface was only seen in inflamed tissues. These results suggest that VAP-1 is both an optimal candidate for anti-adhesive therapy and a potential target molecule for imaging inflammation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Adhesion Molecules
/
Amine Oxidase (Copper-Containing)
/
Inflammation
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Am J Pathol
Year:
2000
Document type:
Article
Affiliation country:
Finlandia