Progressive infection in a subset of HIV-1-positive chimpanzees.
J Infect Dis
; 182(4): 1051-62, 2000 Oct.
Article
in En
| MEDLINE
| ID: mdl-10979899
ABSTRACT
Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)-1; however, infected animals usually maintain normal numbers of CD4(+) T lymphocytes and do not develop immunodeficiency. We have examined 10 chronically infected HIV-1-positive chimpanzees for evidence of progressive infection. In addition to 1 animal that developed AIDS, 3 chimpanzees exhibit evidence of progressive HIV infection. All progressors have low CD4(+) T cell counts (<200 cells/microL), severe CD4CD8 inversion, and marked reduction in interleukin-2 receptor expression by CD4(+) T cells. In comparison with HIV-positive nonprogressor chimpanzees, progressors have higher plasma and lymphoid virus loads, greater CD38 expression in CD8(+)/HLA-DR(+) T cells, and greater serum concentrations of soluble tumor necrosis factor type II receptors and beta2-microglobulin, all markers of HIV progression in humans. These observations show that progressive HIV-1 infection can occur in chimpanzees and suggest that the pathogenesis of progressive infection in this species resembles that in humans.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antigens, CD
/
HIV Infections
/
Acquired Immunodeficiency Syndrome
/
HIV Seropositivity
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Infect Dis
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos