Role of angiogenesis in benign, premalignant and malignant vulvar lesions.
J Reprod Med
; 45(8): 609-12, 2000 Aug.
Article
in En
| MEDLINE
| ID: mdl-10986676
ABSTRACT
OBJECTIVE:
To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions. STUDYDESIGN:
Immunohistochemical demonstration of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in normal vulvar skin, lichen sclerosus, vulvar intraepithelial neoplasia (VIN) and vulvar cancer.RESULTS:
VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions.CONCLUSION:
Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Vulvar Diseases
/
Vulvar Neoplasms
/
Carcinoma in Situ
/
Lichen Sclerosus et Atrophicus
/
Neovascularization, Pathologic
Limits:
Female
/
Humans
Language:
En
Journal:
J Reprod Med
Year:
2000
Document type:
Article
Affiliation country:
Reino Unido