Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay.
J Antibiot (Tokyo)
; 53(7): 657-63, 2000 Jul.
Article
in En
| MEDLINE
| ID: mdl-10994806
ABSTRACT
We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report the isolation and structure elucidation of the compounds and describe some of their biological properties.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
2000
Document type:
Article
Affiliation country:
Reino Unido