Effect of blood transfusions on disease-free interval after rectal cancer surgery.
Hepatogastroenterology
; 47(34): 1002-5, 2000.
Article
in En
| MEDLINE
| ID: mdl-11020864
ABSTRACT
BACKGROUND/AIMS:
To assess retrospectively the impact of perioperative blood transfusions on disease-free interval after curative surgery of rectal cancer.METHODOLOGY:
One hundred and seven (107) subjects (65 men and 42 women, median age 67) underwent anterior resection of the rectum for rectal cancer between 1990 and 1996. Thirty-six (37%) were transfused perioperatively. Outcome variables measured were age, sex, distance of the tumor from the anal verge, type of stapled anastomosis, protective colostomy, cancer-free margin in the specimen, grading and staging, leak of the suture line, transfusion, number of blood units given, and adjuvant therapy.RESULTS:
Transfusion, nodes involvement and adjuvant therapy had a significant impact on disease-free interval at the univariate analysis. The estimated probability of cancer-free survival at 5 years was 81% for the not transfused, and 63% for the transfused patients (P < 0.05). At multivariate analysis, nodes involvement resulted significantly and independently related to time to recurrence (P < 0.05) but also perioperative blood transfusion showed an important role as independent risk factor for rectal cancer relapse (P = 0.05).CONCLUSIONS:
This study suggests that blood transfusion is likely to have a detrimental effect on disease-free interval after resective surgery of rectal cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectal Neoplasms
/
Transfusion Reaction
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Hepatogastroenterology
Year:
2000
Document type:
Article
Affiliation country:
Italia