An N-methyl-D-aspartate antagonist, MK-801, preferentially reduces electroconvulsive shock-induced phosphorylation of p38 mitogen-activated protein kinase in the rat hippocampus.
Neurosci Lett
; 296(2-3): 101-4, 2000 Dec 22.
Article
in En
| MEDLINE
| ID: mdl-11108991
ABSTRACT
Electroconvulsive shock (ECS) activates the mitogen-activated protein kinase (MAPK) family in the rat hippocampus, but the signaling pathways for this activation are not well understood. We investigated whether N-methyl-D-aspartate (NMDA) receptor mediated signaling is involved in the phosphorylation-activation of the MAPK family. The NMDA receptor antagonist, MK-801, dose-dependently reduced ECS-induced phosphorylation of p38 and its upstream kinase MKK6 up to 1 mg/kg. MK-801 also reduced the phosphorylation of ERK1/2 and MEK1, but only at high dosage, 2 mg/kg. Moreover, the reduction in the phosphorylation of p38 and MKK6 was greater than that of ERK1/2 and MEK1. Our results suggest that ECS activates p38 and ERK1/2 partly through an NMDA receptor-mediated signaling system in the rat hippocampus and that NMDA receptor mediated signaling is more responsible for the activation of the MKK6-p38 pathway than the MEK1-ERK pathway.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dizocilpine Maleate
/
Receptors, N-Methyl-D-Aspartate
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Electroshock
/
Hippocampus
/
Neurons
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2000
Document type:
Article
Affiliation country:
Corea del Sur