Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer.
Am J Surg
; 180(4): 299-304, 2000 Oct.
Article
in En
| MEDLINE
| ID: mdl-11113440
ABSTRACT
BACKGROUND:
We hypothesized that wide-field brachytherapy (BRT) after margin negative excision would result in complication rates, local recurrence rates, and cosmesis scores equivalent to external beam radiotherapy (ERT).METHODS:
Patients with T(is,1,2) tumors less than or equal to 4 cm, 0 to 3 positive axillary nodes, and negative inked surgical margins were entered prospectively into BRT phase I/II trial. Patients who met the eligibility criteria for BRT but were treated with ERT during the same time period were retrospectively identified as controls. A blinded panel of healthcare professionals graded cosmetic outcome.RESULTS:
Fifty patients with 51 breast cancers received BRT from January 1992 to October 1993. We identified 94 patients eligible for BRT but concurrently treated with ERT. At a median follow-up of 75 months, the two groups were similar for grade III treatment toxicities, local/regional recurrence rates, and cosmesis scores.CONCLUSIONS:
For selected breast cancer patients undergoing breast-conserving therapy, BRT is an attractive alternative to ERT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Care
/
Brachytherapy
/
Breast Neoplasms
/
Mastectomy, Segmental
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Am J Surg
Year:
2000
Document type:
Article
Affiliation country:
Estados Unidos