Caspase activation is required for terminal erythroid differentiation.
J Exp Med
; 193(2): 247-54, 2001 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-11208865
ABSTRACT
The cysteine proteases known as caspases play a central role in most apoptotic pathways. Here, we show that caspase inhibitors arrest the maturation of human erythroid progenitors at early stages of differentiation, before nucleus and chromatin condensation. Effector caspases such as caspase-3 are transiently activated through the mitochondrial pathway during erythroblast differentiation and cleave proteins involved in nucleus integrity (lamin B) and chromatin condensation (acinus)without inducing cell death and cleavage of GATA-1. These observations indicate a new function for caspases as key proteases in the process of erythroid differentiation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caspases
/
Erythrocytes
/
Erythropoiesis
Limits:
Humans
Language:
En
Journal:
J Exp Med
Year:
2001
Document type:
Article
Affiliation country:
Francia