Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains.
Neurosci Lett
; 300(3): 179-81, 2001 Mar 16.
Article
in En
| MEDLINE
| ID: mdl-11226640
ABSTRACT
Glial cell line-derived neurotrophic factor (GDNF) was measured for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme-linked immunosorbent assay. In both groups, the levels of GDNF in the various brain regions were lower (pg/mg protein) than those of brain-derived growth factor (ng/mg order), and were significantly higher in the nigro-striatal dopaminergic regions (substantia nigra, caudate nucleus, putamen) than in the cerebellum and frontal cortex (P < 0.05). However, the content of GDNF in the dopaminergic regions showed no significant difference between parkinsonian and control patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Putamen
/
Substantia Nigra
/
Caudate Nucleus
/
Brain-Derived Neurotrophic Factor
/
Nerve Growth Factors
/
Nerve Tissue Proteins
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurosci Lett
Year:
2001
Document type:
Article
Affiliation country:
Japón