Combination effect of vancomycin and beta-lactams against a Staphylococcus aureus strain, Mu3, with heterogeneous resistance to vancomycin.
Antimicrob Agents Chemother
; 45(4): 1292-4, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11257050
ABSTRACT
We tested the combined activity of vancomycin and seven beta-lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested beta-lactams exhibited an additive effect at or near their MICs, while all showed an antagonistic effect at lower, sub-MIC levels. This study implicated the unpredictable nature of combination therapy of beta-lactams and vancomycin against S. aureus with reduced susceptibility to vancomycin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Staphylococcus aureus
/
Vancomycin
/
Vancomycin Resistance
/
Beta-Lactams
/
Drug Therapy, Combination
/
Anti-Bacterial Agents
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2001
Document type:
Article
Affiliation country:
Japón