Peptide and recombinant antigens for protection against bacterial middle ear infection.
Vaccine
; 19(17-19): 2323-8, 2001 Mar 21.
Article
in En
| MEDLINE
| ID: mdl-11257356
ABSTRACT
Passive immunization of chinchillas with serum specific for either LB1 or for LPD-LB1 (f)(2,1,3) prior to challenge with heterologous NTHI isolates (relative to diversity in region three of P5-fimbrin), significantly inhibited the signs and incidence of otitis media (P < or = 0.01) induced by any of the challenge isolates. The ability of these antisera to induce total eradication of NTHI from the nasopharynx was not however equivalent among challenged cohorts. The data thus suggested that while early, complete eradication of NTHI from the nasopharynx was highly protective, reduction of the bacterial load to below a critical threshold level appeared to be similarly effective. Both immunogens thus remain strong vaccine candidates.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Otitis Media
/
Haemophilus Vaccines
Limits:
Animals
/
Humans
Language:
En
Journal:
Vaccine
Year:
2001
Document type:
Article
Affiliation country:
Estados Unidos