2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Proc Natl Acad Sci U S A
; 98(7): 3662-5, 2001 Mar 27.
Article
in En
| MEDLINE
| ID: mdl-11259648
ABSTRACT
Two types of endogenous cannabinoid-receptor agonists have been identified thus far. They are the ethanolamides of polyunsaturated fatty acids--arachidonoyl ethanolamide (anandamide) is the best known compound in the amide series--and 2-arachidonoyl glycerol, the only known endocannabinoid in the ester series. We report now an example of a third, ether-type endocannabinoid, 2-arachidonyl glyceryl ether (noladin ether), isolated from porcine brain. The structure of noladin ether was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and was confirmed by comparison with a synthetic sample. It binds to the CB(1) cannabinoid receptor (K(i) = 21.2 +/- 0.5 nM) and causes sedation, hypothermia, intestinal immobility, and mild antinociception in mice. It binds weakly to the CB(2) receptor (K(i) > 3 microM).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Drug
/
Brain Chemistry
/
Glycerides
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2001
Document type:
Article
Affiliation country:
Israel