Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies.
Bioorg Med Chem Lett
; 11(7): 883-6, 2001 Apr 09.
Article
in En
| MEDLINE
| ID: mdl-11294383
ABSTRACT
In vitro assays on a series of cis- and trans-octahydrobenzo[g]quinolines indicated an unusual trend of affinities at the dopaminergic receptors and alpha adrenoceptors. The trans N-benzyl analogues exhibited affinity at the alpha2 as well as the D1-like receptors whereas their N-unsubstituted congeners showed a distinct preference for the alpha2 adrenoceptor. Enhanced activity for the alpha2 receptors was also exhibited by the cis N-benzylated isomers. These observations are interpreted by theoretical calculations.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Dopamine Agents
/
Receptors, Adrenergic, alpha
/
Receptors, Adrenergic, alpha-2
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2001
Document type:
Article
Affiliation country:
Grecia