Why is there so much end-stage renal failure of undetermined cause in UK Indo-Asians?
QJM
; 94(4): 187-93, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11294961
ABSTRACT
There is a high incidence of end-stage renal failure (ESRF) of undetermined cause in the Indo-Asian population of the UK. We studied patients presenting from the district of Brent and Harrow, which has a large Indo-Asian community, and whose renal services are largely provided by our centre. The diagnosis and ethnicity of patients starting renal replacement therapy and/or undergoing renal biopsy were collated. The incidences of ESRF, rates of renal biopsy and underlying diagnoses were calculated for Indo-Asians and Caucasians. Requirement for renal replacement therapy in Indo-Asians presenting to our centre from Brent and Harrow was 221/10(6)/year; no underlying diagnosis was identified in 77/10(6)/year. Renal biopsy rate in these patients was 456/10(6)/year, and the diagnostic categories significantly over-represented compared to Caucasians were hypertension and ischaemia, focal segmental glomerulosclerosis (FSGS), idiopathic interstitial nephritis (IIN), diabetic nephropathy, minor glomerular abnormality, lupus nephritis and non-specific advanced chronic renal disease (p<0.001). The first three of these had a combined incidence of 135/10(6)/year in Indo-Asians and 31/10(6)/year in Caucasians. ESRF of undetermined cause is common in UK Indo-Asians, as is requirement for renal biopsy. Hypertension with ischaemia, FSGS and IIN are over-represented in the Indo-Asian population, and should be targeted for early diagnosis and treatment in this group.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kidney Failure, Chronic
Type of study:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Country/Region as subject:
Asia
/
Europa
Language:
En
Journal:
QJM
Journal subject:
MEDICINA
Year:
2001
Document type:
Article
Affiliation country:
Reino Unido