The trigeminovascular system in bacterial meningitis.
Microsc Res Tech
; 53(3): 188-92, 2001 May 01.
Article
in En
| MEDLINE
| ID: mdl-11301494
ABSTRACT
Headache as a cardinal symptom of acute meningitis reflects activation of trigeminal afferents from the meninges. With their perivascular endings, these fibers form the so-called trigeminovascular system (TVS), which releases proinflammatory neuropeptides upon nociceptive stimulation. In the present article, we review a role of the TVS in enhancing the early inflammatory response of bacterial meningitis. Furthermore, we discuss inhibition of neuropeptide release from the TVS using 5HT(1B/D) agonists as a potential new anti-inflammatory treatment strategy for early bacterial meningitis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trigeminal Nerve
/
Meningitis, Bacterial
/
Neurogenic Inflammation
/
Meninges
Limits:
Animals
/
Humans
Language:
En
Journal:
Microsc Res Tech
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2001
Document type:
Article
Affiliation country:
Alemania