Combined revascularization strategy for acute myocardial infarction in patients with intracoronary thrombus: preceding intracoronary thrombolysis and subsequent mechanical angioplasty.
Jpn Circ J
; 65(4): 251-6, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11316117
ABSTRACT
Thrombus in the infarct-related artery is one of the limitations for flow restoration in primary percutaneous transluminal coronary angioplasty (PTCA) treatment for acute myocardial infarction (AMI). The present study investigated the benefit of preceding intracoronary thrombolysis (ICT) by retrospectively analyzing acute phase flow restoration in 80 AMI patients with intracoronary thrombus 40 undergoing primary PTCA alone (primary PTCA group) and 40 treated with preceding ICT plus PTCA (combined group). Acute phase Thrombolysis in Myocardial Infarction (TIMI) grade flow was as follows TIMI 0/1 35.0% vs 12.5% for the primary PTCA group and the combined group, p=0.06; TIMI 2 7.5% vs 15.0%, p=NS; TIMI 3 57.5% vs 72.5%, p=NS). In the subgroup analysis, it was also less in the combined group among 33 patients with a left anterior descending coronary artery (LAD) lesion (42.1 % vs 7.1%, p=0.08), but not among the remaining 47 with either a right coronary artery or left circumflex artery lesion. The combined therapy may potentially provide better acute phase flow restoration in AMI patients with an intracoronary thrombus in a LAD lesion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Thrombosis
/
Urokinase-Type Plasminogen Activator
/
Angioplasty, Balloon, Coronary
/
Thrombolytic Therapy
/
Fibrinolytic Agents
/
Myocardial Infarction
Type of study:
Etiology_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Jpn Circ J
Year:
2001
Document type:
Article
Affiliation country:
Japón