Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks.
Biol Psychiatry
; 49(10): 832-47, 2001 May 15.
Article
in En
| MEDLINE
| ID: mdl-11343680
ABSTRACT
BACKGROUND:
Prior studies using simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks.METHODS:
Event-related potentials of 66 patients (14 unmedicated) diagnosed with schizophrenia (n = 46) or schizoaffective disorder (n = 20) and 32 healthy adults were recorded from 30 scalp electrodes during two oddball tasks using consonant-vowel syllables or complex tones. Overlapping ERP components were identified and measured by covariance-based principal components analysis.RESULTS:
Schizophrenic patients showed marked, task-independent reductions of early negative potentials (N1, N2) but not reduced P3 amplitude or abnormal P3 asymmetry. Task-related hemispheric asymmetries of the N2/P3 complex were similar in healthy adults and schizophrenic patients. Poorer task performance in patients was related to ERP amplitudes, but could not account for reductions of early negativities.CONCLUSIONS:
The findings suggest that both patients and control subjects activated lateralized cortical networks required for pitch (right frontotemporal) and phoneme (left parietotemporal) discrimination. Task-independent reductions of negativities between 80 and 280 msec after stimulus onset suggest a deficit of automatic stimulus classification in schizophrenia, which may be partly compensated by later effortful processing.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Speech Perception
/
Brain
/
Evoked Potentials
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Biol Psychiatry
Year:
2001
Document type:
Article
Affiliation country:
Estados Unidos