Regenerative capacity of human satellite cells: the mitotic clock in cell transplantation.
Neurol Sci
; 21(5 Suppl): S943-51, 2000.
Article
in En
| MEDLINE
| ID: mdl-11382194
ABSTRACT
In this communication, we will review the problems caused by cell-mediated gene therapy, taking skeletal muscle as a physiological model. In particular we have utilised vectors transferring telomerase under the control of retroviral promoters into human satellite cells. The set of results presented here has several implications regarding gene therapy trials. Nevertheless, more experiments will be required to fully validate this cellular model and to use telomerase to safely extend the lifespan of putative gene therapy vectors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Therapy
/
Tissue Transplantation
/
Muscle Fibers, Skeletal
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2000
Document type:
Article
Affiliation country:
Francia