Insulin resistance is increased by transdermal estrogen therapy in postmenopausal women with cardiac syndrome X.
Cardiology
; 95(1): 31-4, 2001.
Article
in En
| MEDLINE
| ID: mdl-11385189
ABSTRACT
Estrogen has been reported to have both short- and long-term effects on the cardiovascular system. However, it remains to be examined how short-term transdermal estrogen therapy (TET) affects insulin sensitivity (SI) in patients with cardiac syndrome X (CSX), who are characterized by elevated insulin resistance. SI was assessed in a randomized, double-blind, placebo-controlled crossover study by minimal model analysis in seven postmenopausal women with CSX treated by TET. SI decreased by 32 +/- 8.3%, from 5.94 +/- 1.14 at baseline to 3.61 +/- 0.40 [(10(-4) x min(-1))/(microU/ml)] during TET (p = 0.03). Time to the onset of symptoms increased from 414.2 +/- 51.0 s at baseline to 450.0 +/- 53.2 s (p = 0.04). We conclude that TET increases SI in postmenopausal women with CSX. This effect is unrelated to the beneficial anti-ischemic effects on exercise duration.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Estrogen Replacement Therapy
/
Microvascular Angina
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Cardiology
Year:
2001
Document type:
Article
Affiliation country:
Estados Unidos