Role of the M1 receptor in regulating circadian rhythms.
Life Sci
; 68(22-23): 2467-72, 2001 Apr 27.
Article
in En
| MEDLINE
| ID: mdl-11392614
ABSTRACT
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Suprachiasmatic Nucleus
/
Receptors, Muscarinic
/
Circadian Rhythm
/
Cyclic GMP
/
Neurons
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Life Sci
Year:
2001
Document type:
Article
Affiliation country:
Estados Unidos